Mike Lawlor

LawlorMike Lawlor is MD, PhD, Assistant Professor of Pathology; Director of the  Pediatric Pathology NeuromuscularLaboratory, Milwaukee, WI, USA

Dr. Lawlor’s clinical responsibilities include the diagnosis of nerve, muscle, brain and spinal cord specimens from surgical and autopsy material, with an emphasis on pediatric muscle and nerve biopsies.  His research laboratory studies animal models of congenital myopathy (X-linked myotubular myopathy, in most cases) in an effort to further understand these diseases and develop new treatments.

Research Interests:

  • Pediatric muscle disease (X-linked myotubular myopathy)
  • Preclinical trials of novel therapeutic agents
  • Skeletal muscle pathology
  • Skeletal muscle physiology
  • In vitro models of skeletal muscle function and disease

 

On May 7, 2016 Mike Lawlor gave a talk at the European family conference #TogetherEvenStronger on the topic:

What is a tissue bank and how can it help in the preparation of clinical trials?

This talk will discuss options for the donation of patient tissue for research use through the CMD TissueRepository, and discuss how such donations have assisted in adapting animal model studies in preparation  for the upcoming gene therapy clinical trial for X-linked myotubular myopathy.

Scientific publications

David L. Mack, Karine Poulard, Melissa A. Goddard, Virginie Latournerie, Jessica M. Snyder, Robert W. Grange, Matthew R. Elverman, Jérôme Denard, Philippe Veron, Laurine Buscara, Christine Le Bec, Jean-Yves Hogrel, Annie G. Brezovec, Hui Meng, Lin Yang, Fujun Liu, Michael O’Callaghan, Nikhil Gopal, Valerie E. Kelly, Barbara K. Smith, Jennifer L. Strande, Fulvio Mavilio, Alan H. Beggs, Federico Mingozzi, Michael W. Lawlor, Ana Buj-Bello, Martin K. Childers (2017)
Systemic AAV8-mediated gene therapy drives whole-body correction of myotubular myopathy in dogs, Molecular Therapy [in press, DOI: http://dx.doi.org/10.1016/j.ymthe.2017.02.004]

Lawlor MW, Armstrong D, Viola MG, Widrick JJ, Meng H, Grange RW, Childers MK, Hsu CP, O’Callaghan M, Pierson CR, Buj-Bello A, Beggs AH. (2013), Enzyme replacement therapy rescues weakness and improves muscle pathology in mice with x-linked myotubular myopathy. Hum Mol Genet. 2013 Apr 15;22(8):1525-38.
This publications explains successful enzyme replacement in mice.

 

Further Information